间充质干细胞在实验性自身免疫性视网膜炎（EAU）中对T细胞亚群动态改变的作用
临床实验免疫学 2013 年1月28
间充质干细胞在实验性自身免疫性视网膜炎（EAU）中对T细胞亚群动态改变的作用
报道发现间充质干细胞(MSC)能够缓解大鼠EAU症状，是与MSC对T细胞亚群及其分泌的细胞因子作用相关。在整个EAU过程中，MSC降低Th1和Th17细胞因子的产生，同时提高了Th2和Treg细胞因子（IL-10，TGF）的分泌，重建Th17/Treg平衡，在疾病缓解过程中意义重大。
Clin Exp Immunol. 2013 Jan 28. doi: 10.1111/cei.12080. [Epub ahead of print]
The Effect of Mesenchymal Stem Cells on Dynamic Changes of T Cell Subsets in Experimental Autoimmune Uveoretinitis.
Li G, Yuan L, Ren X, Nian H, Zhang L, Han ZC, Li X, Zhang X.
Tianjin Medical University Eye Hospital & Eye Institute, No. 251, Fukang Road, Nankai District, Tianjin, China, 300384.
Abstract
Mesenchymal stem cells (MSCs) are being extensively explored as a promising treatment for autoimmune diseases. We recently reported that MSCs could ameliorate experimental autoimmune uveoretinitis (EAU) in rats. In this study, we further examined the effects of MSCs on the dynamics of T cell subsets in both eye and spleen and their cytokine production during the course of EAU. We focused on when and where the MSCs had inhibitory effects on Th1 and Th17 cells and how long the inhibitory effect lasted, so as to provide more mechanistic evidence for MSCs on the treatment of uveitis. Compared to the control group, administration of MSCs significantly decreased the production of Th1 and Th17 cytokines, while elevated the production of Th2 and Treg cytokines (IL-10 and TGF-b) during the entire course of EAU. Correspondingly, the dynamic levels of IL-17 in the aqueous humor (AqH) were reduced in MSCs treated rats, Moreover, the ratio of Th17/Treg cells in both spleen and eye was decreased. These results provide powerful evidence that MSCs can negatively regulate both Th1 and Th17 responses and restore the balance of Th17/Tregs in the whole course of EAU, which is important for the regression of the disease.
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