间充质干细胞支持B淋巴细胞增殖与终末分化
间充质干细胞（MSC）针对T淋巴细胞免疫调节功能被广泛关注，同样地对B淋巴细胞具有调节作用，能够促进B淋巴细胞增殖、分化为浆细胞，并增强抗体产生。其机制可能是通过PGE2发挥作用，而不是I白细胞介素-6.。
延伸：间充质干细胞对T淋巴细胞，B淋巴细胞，树突状细胞、NK细胞的活性均有重要的调节，所以MSC在免疫系统疾病，特别是自身免疫性疾病中具有极大的治疗潜能。有鉴于免疫系统的复杂性，在应用MSC治疗时，更需小心谨慎。
1，Cell Physiol Biochem. 2012;30(6):1526-37. doi: 10.1159/000343340. Epub 2012 Dec 10.
Mesenchymal stem cells support proliferation and terminal differentiation of B cells.
Ji YR, Yang ZX, Han ZB, Meng L, Liang L, Feng XM, Yang SG, Chi Y, Chen DD, Wang YW, Han ZC.
Source
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, China.
Abstract
BACKGROUND:
Mesenchymal stem cells (MSC) play important roles in modulating the activities of T lymphocytes, dendritic cells and natural killer cells. These immunoregulatory properties of MSC suggest their therapeutic potential in autoimmune diseases. However, the effects of MSC on B cells are still poorly understood. The present study was designed to investigate the interaction between MSC and B cells both in vitro and in vivo, and to determine the possible mechanism of action.
DESIGN AND METHOD:
The effect of human umbilical cord mesenchymal stem cells (UC-MSC) on proliferation and differentiation of B-cells were characterized in vitro, and we also tested the immunoregulatory properties of mouse bone marrow MSC (BM-MSC) on T cell dependent and independent antibody production in vivo in mice.
RESULTS:
Treatment with human UC-MSC resulted in an increase of proliferation, differentiation of B cells into plasma cells and production of antibodies in vitro. Mouse BM-MSC significantly enhanced T cell dependent and independent antibodies production in vivo in mice. PGE2 partially mediated the immunosuppressive activity of human UC-MSC but IL-6 did not regulate this activity.
CONCLUSION:
MSC promote proliferation and differentiation of B cells in vitro and in vivo partially through PGE2 but not IL-6.
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